first of all thanks Hiren, i had a same problem as like you but using your solution i sort it out
in aspx;
inside body section
write the following
<body onload="fixform()">
then write a javascript
<script type="text/javascript">
function fixform()
{
document.getElementById("Form1").target = '';
}
remember you have set target ='_blank' onClientClick
for viz.:
<asp:button id="btnPrint" runat="server" text="Print" onclick="btnPrint_Click" onclientclick="Form1.target='_blank'" xmlns:asp="#unknown" />