1. Use configuration(or App Settings)
2. Access data from a Shared folder.
3. Always keep data in a relative location to the main exe.
Eg: Let Your application path is D:\MyAppFolder\myapp.exe
Let your data path is D:\MyAppFolder\MyData\SomedatabaseFile.ext
So your DB can be accessed as :
string DBPath = System.IO.Path.Combine(System.IO.Path.GetDirectoryName(Assembly.GetExecutingAssembly().Location), "MyData\\Somedb.mdb");