You can try following regex.
string myCheck = "^[E][S]\\w*";
string myStr = "ES12121";
if(Regex.IsMatch(myStr,myCheck,RegexOptions.IgnoreCase))
{
Console.WriteLine("Yes, it starts with ES");
}
else
{
Console.WriteLine("No Its not!!");
}
Console.ReadKey();
Hope that helps. If it helps, mark the answer as solution.
Thanks
Milind