this way...
Dim col_Prof As New DataGridViewTextBoxColumn()
With col_Prof
.Name = "xx"
.HeaderText = "xx"
.ReadOnly = False
.DataPropertyName = "Column1"
End With
dgvUserDetails.Columns.Add(col_Prof)
dgvUserDetails.AutogenerateColumns = false
dgvUserDetails.Datasource = Ds.Tables(0)
Happy Coding!
:)