Read the error message: it's pretty clear.
Quote:
It is already opened exclusively by another user, or you need permission to view its data.
So either the file is in use somewhere else in your app, or a different app; or the file or part of the folder tree it is in is not available to your user because of permission problems.
Start by checking which user is trying to access the file (the "AspProject" implies web based, so it's probably IIS on your dev machine which is not running under your UserID) and then check the file tree to ensure that the folder and file are read and write accessible to that user.