Using Javascript, you can do it using
setAttribute()[
^] method.
var elem = document.getElementById("ddl_State");
elem.setAttribute("class", "select validate[required] Disabled");
Using jQuery, it's pretty simple:
$("#ddl_State").attr("class", "select validate[required] Disabled");
[Edit]
.prop()[
^] is recommended way and supported in newer versions of jQuery. So below code is better:
$("#ddl_State").prop("class", "select validate[required] Disabled");