Make .EXE of vb.net Project

Follow below steps to create set up file

1) Select Add->New Project -> select Other Project Type set up and deployment

2) Choose setup file in Solution Explorer right click then choose view -> File System

3) In the Application folder choose right click add --> File and choose your .mdb database add it. Along with before you add your project .exe file (or) Primary output of the file

4) If you need shortcut for set up file then right of primary out file and create short cut and cut this shortcut select user desktop option and paste it rename it.

5) Again right click and create another one short cut in the Application then paste it in USer's Programs menu (create one folder and place it)

6) Rebuild set up file and see in your setup file folder setup file is created taken that msi file and install it in other PC.

all steps explained with screen shot refer this article
http://www.dotnetspider.com/resources/43059-How-Create-Setup-file-for-NET-windows.aspx

Other option take whole bin folder files copy and paste in other system just execute that .exe file on double click