You are pretty much on a loser there - .NET does not easily support numbers larger than int64 - and that is an int128, which won't even fit in a decimal...
There is the BigIntger class:
Dim hexString As String = "4247f4e627ca7065145406ab01f7f7e3"
Dim bi As BigInteger = BigInteger.Parse(hexString, System.Globalization.NumberStyles.HexNumber)
But whether that is useful to you depends on what you are planning on doing with the data...