You need to change like below to pass the dropdown list value to database. Below in highlighted with underline.
string connection = "Data Source=C:\\Documents andSettings\\Administrator\\My Documents\\my1.mdb";
string cl = DropDownList1.SelectedItem.Text;
string query = "Select * from fee where course=" + c1; AccessDataSource ads = new AccessDataSource("C:\\Documents and Settings\\Administrator\\My Documents\\my1.mdb", query);
GridView1.DataSource = ads;
GridView1.DataSourceID = String.Empty;
GridView1.DataBind();
Hope it helps.