Based on your question, it looks like you want to find a smaller picture inside a larger picture and then you want to crop the image to be just the smaller image inside.
To start with, here is a great CP article on how to work with images (including cropping):
Image Processing using C#[
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To find that smaller image, if you don't know the coordinates and you don't want the user to draw a box on the screen to indicate the coordinates (which would be best, by the way), you could try to find the right place by looking for a particular pattern of pixels (say a box around the picture). Here is a post that might have some useful code that you could start from:
http://www.dreamincode.net/forums/topic/201783-c%23-trying-to-find-a-smaller-image-inside-a-larger-image-need-help/[
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