If you want to do at UI level or BL level, you can create a new datatable as your datasource. For that, define the expected columns from query result and add a new column as sum that you need.
Iterate Row-wise though the datatable you got from DB. Set the values of all the columns row-wise. Lets say, something like:3
foreach (DataRow dr in dt.Rows)
{
tempValueIn1stColumn = Convert.ToDouble(dr["1st Column Name"]);
tempValueIn2ndColumn = Convert.ToDouble(dr["2nd Column Name"]);
tempValueIn3rdColumn = tempValueIn1stColumn + tempValueIn2ndColumn;
}
Though this can be done, but for best performance doing this in database would be advisable.